Many proteins regulate these trafficking pathways, with the Ras-like small GTP-binding proteins (Rab-GTP-binding proteins) playing a central role. While some receptors are sorted for lysosomal degradation, other receptors are recycled back to the plasma membrane, either in a direct pathway from EE (fast recycling) or indirectly through the endocytic recycling compartment (ERC) (reviewed in ( 1, 2)). Upon endocytosis, newly internalized vesicles are directed to early endosomes (EE).
Overall, our data suggest a model in which Rab35 is a critical upstream regulator of MICAL-L1 and Arf6, while both MICAL-L1 and Arf6 regulate Rab8a function.Įndocytosis is a highly conserved process across species in which nutrients, and lipids are internalized into the cells. Moreover, we demonstrate that Arf6 forms a complex with MICAL-L1 and plays a role in its recruitment to tubular endosomes. Over-expression of active Rab35 impairs the recruitment of MICAL-L1 to tubular recycling endosomes, whereas Rab35 depletion promotes enhanced MICAL-L1 localization to these structures. First, we demonstrate that Rab35 is a MICAL-L1 binding partner in vivo. In this study, we identify two GTP-binding proteins as interaction partners of the endocytic regulatory protein MICAL-L1. Despite our familiarity with many of the key regulatory proteins involved in this process, our understanding of the mode by which these proteins cooperate and the sequential manner in which they function remains limited. A variety of small GTP-binding proteins regulate receptor recycling. Once internalized, receptors can either be degraded or recycled back to the plasma membrane. Once solidified, we will focus our efforts on marketing and advertising the 988-dialing code throughout Michigan.Endocytosis is a conserved process across species in which cell surface receptors and lipids are internalized from the plasma membrane. Our current focus and priority is to develop and strengthen infrastructure to increase Michigan’s capacity to meet needs and requirements.
Public awareness activities and marketing are set to begin in early 2023. In doing so, the Michigan Legislature gave Michigan a head start in developing a comprehensive statewide call center. The Michigan Legislature gave Michigan an advantage by codifying and funding the Michigan Crisis and Access Line back in 2020. It does have its’ own number because it predates 988, but Michiganders can call either number to get help.
The MiCAL staff answer Michigan’s 988 calls. The Michigan Crisis and Access Line (MiCAL) is Michigan’s statewide crisis and access line. The Lifeline responds 24/7 to calls, chats, or texts from anyone who needs support for suicidal, mental health, and/or substance use crisis, and connects those in need with trained crisis counselors. 988 is not intended only for suicide-related crises. In the end, 988 is an easier-to-remember way to access a strengthened and expanded network of crisis call centers. After July 16, 2022, using either number will get people to the same services. Moving to 988 does not mean the 1-80 number goes away.
People can also dial 988 if they are worried about a loved one who may need crisis support. The 988 Suicide and Crisis Lifeline is a 24/7 toll-free nationwide hotline, made up of a network of independently operated and funded local call centers (200+) across the country.Īs of July 16, 2022, 988 will be the new three-digit dialing code connecting people to the existing National Suicide Prevention Lifeline (NSPL), where compassionate care and accessible support is available for anyone experiencing mental health-related distress-whether that is thoughts of suicide, mental health or substance use crisis, or any other kind of emotional distress.